Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population.

نویسندگان

  • Jianyu Han
  • Jianfeng Han
  • Dongmei Yu
  • Jinling Xiao
  • Yong Shang
  • Lijun Hao
چکیده

OBJECTIVE To study the association between ADAM33 and keloid scars in the northeastern Chinese population. METHODS A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1 ) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS We observed the frequency of the rs612709 A allele exhibited a significantly decreased frequency in cases than in controls(22 vs.39.6%, P<0.0001) We also found that the frequencies of H2 (GGAAGA) haplotypes was significantly higher in the case group than in the control group (P= 0.041). In contrast, the haplotype H8 (GGGAGG) was more common in the control group than in the case group (P=0.022). CONCLUSIONS Our data suggest that the ADAM33 polymorphisms may be associated with keloid scars in the northeastern Chinese population.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of ADAM33 gene polymorphisms with allergic asthma

Objective(s): Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Materials and Methods: This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal con...

متن کامل

ADAM33 gene polymorphisms in Southwestern Iranian patients with asthma

Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than 100 candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM33. However, the relationship between ADAM33 gene polymorph...

متن کامل

Association Study on ADAM33 Polymorphisms in Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population

BACKGROUND The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. OBJECTIVE To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population. METHODS In a hospital-based case...

متن کامل

Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China.

We evaluated the associations between single nucleotide polymorphisms (SNPs) and haplotypes of the genes encoding a disintegrin and metalloproteinase 33 (ADAM33), cluster of differentiation 14 (CD14), and Toll-like receptor 4 (TLR4) and the susceptibility of developing specific adult phenotypes of bronchial asthma in a Chinese Uygur population. Five SNPs of ADAM33 (T1, T2, and V4), 3 SNPs of CD...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

دوره 34 3  شماره 

صفحات  -

تاریخ انتشار 2014